Compile Data Set for Download or QSAR
Found 38 of ic50 data for polymerid = 5121
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7JD9PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human MKK6 using p38alpha as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5KB8PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human MKK6 using p38alpha as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W380MTPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50536679(CHEMBL4568087)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibition of full-length recombinant human His-tagged MAP2K6 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP27X5PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)copy SMILEScopy InChI
Affinity DataIC50: 388nMAssay Description:Inhibition of human MKK6 using p38a as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TQ63S4PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50592884(CHEMBL3716507)copy SMILES
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C50SMPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VF0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SX6DC7PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged MAP2K6 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP27X5PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50186231((2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)ac...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of MEK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028W77PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MKK6 (4 to end residues) using SAPK2 as substrate incubated for 40 mins by radiometric scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93FGPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50462709(CHEMBL4245507)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MKK6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP77MHPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50429867(CHEMBL2333365)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MKK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC847XPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50232968(CHEMBL4099337)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MKK6 using p38a as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TQ63S4PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged MAP2K6 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N018JCPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MKK6 using p38alpha as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7WT8PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50169959(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Mitogen activated protein kinase 6; Range is 5-10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K9389GPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50558812(CHEMBL4755698)copy SMILES
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MKK6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P272TRPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73F2SPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4H9DPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of MKK6 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7BXVPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged MAP2K6 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP27X5PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50056922(1,4-Dihydroxy-10-methoxy-5,8-dimethyl-3,7-dioxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+4nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8WN0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50115297(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MKK-6, Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RX9BDPPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50115295(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MKK-6, Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RX9BDPPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50115298(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MKK-6, Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RX9BDPPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50118831(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50536678(CHEMBL4550702)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged MAP2K6 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NP27X5PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM29673(1,4,10-Trihydroxy-5-hydroxymethyl-8-methyl-3,7-dio...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+4nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8WN0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MKK6b kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XS5TMTPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM21898(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MKK6 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KS6RBPPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full length human His-tagged MAP2K6 expressed in baculovirus expression system using serine/threonine-3 peptide as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM5CZGPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50056939(4-Formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.25E+5nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8WN0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM92359(Gangleoidin, 4)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+5nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8WN0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM29674(Reduced stictic acid, 8)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+5nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8WN0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM29678(Reduced parellic acid, 9)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+5nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8WN0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50056904(3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+5nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B8WN0PubMed